To Err is Human
نویسندگان
چکیده
We argue for the importance of human error as a significant and oft-overlooked factor in system dependability, and contend that human behavior must be considered in both dependability benchmarks and high-dependability system designs. We support our claims with data illustrating that human-induced failures consistently account for half of all outages, and show that human error accompanies even the simplest system operation and maintenance tasks. We then consider how human behavior might be accounted for in both dependability benchmarks and in the designs of dependable computer systems.
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Estrogen-Related Receptor in Human Breast Carcinoma as a Potent Prognostic Factor
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Introduction: The aim of the present study was to investigate the expression of estrogen-related receptor alpha (ERRα) - an important factor in cellular energy homeostasis regulation - in skeletal muscle of male Wistar rats after four weeks of endurance training and to determine its role with fat metabolism indexes. Methods: In this experimental study, 30 male Wistar rats (eight weeks-ol...
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Estrogen-related receptor alpha (ERR alpha) is an orphan member of the superfamily of nuclear hormone receptors. ERR alpha was initially isolated based on its sequence homology to the estrogen receptor but is not activated by classic estrogens. To identify possible physiologic functions for this orphan receptor, we cloned the mouse ERR alpha cDNA and used it to characterize the expression of ER...
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The estrogen receptor-related receptor gamma (ERR gamma/ERR3/NR3B3) is the newest member of the ERR subfamily that also includes ERR alpha and ERR beta. All three isoforms share a high degree of amino acid identity especially in the DNA binding domain. ERR gamma is a constitutively active transcriptional activator that regulates reporter elements driven by steroidogenic factor 1 response elemen...
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Background and purpose: Estrogen-related receptor α (ERR-α) and transcriptional activator (PGC-1α) are important factors involved in regulating cellular energy. The aim of this study was to evaluate the expression of PGC1α, ERRα genes after six weeks of endurance training and MitoQ supplementation in skeletal muscle of male Wistar rats and to determine their role in lipid metabolism indices. ...
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